Study of a cyclopamine glucuronide prodrug for the selective chemotherapy of glioblastoma

F Hamon, B Renoux, C Chadéneau, JM Muller…

Index: Hamon, Florian; Renoux, Brigitte; Chadeneau, Corinne; Muller, Jean-Marc; Papot, Sebastien European Journal of Medicinal Chemistry, 2010 , vol. 45, # 4 p. 1678 - 1682

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Citation Number: 20

Abstract

The first glucuronide prodrug of the hedgehog signaling inhibitor cyclopamine was synthesized. The carbamoyl derivatisation of cyclopamine significantly decreased its toxicity towards the U87 human glioblastoma cell line. However, when the prodrug was incubated ...