Ti/Ni-Mediated Inter-and Intramolecular Conjugate Addition of Aryl and Alkenyl Halides and Triflates

…, A Millán, ML Marcos, LA de Cienfuegos…

文献索引：Marquez, Irene R.; Miguel, Delia; Millan, Alba; Marcos, M. Luisa; De Cienfuegos, Luis Alvarez; Campana, Araceli G.; Cuerva, Juan M. Journal of Organic Chemistry, 2014 , vol. 79, # 4 p. 1529 - 1541

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被引用次数: 5

摘要

In this work, we show that the unique combination of a nickel catalyst and Cp2TiCl allows the direct conjugate addition of aryl and alkenyl iodides, bromides, and to a lesser extent, chlorides and triflates to α, β-unsaturated carbonyls at room temperature, without requiring the previous formation of an organometallic nucleophile. The reaction proceeds inter-and intramolecularly with good functional group compatibility, which is key for the development ...