A rational approach to the design of flavones as xanthine oxidase inhibitors

L Costantino, G Rastelli, A Albasini

文献索引：Costantino; Rastelli; Albasini European Journal of Medicinal Chemistry, 1996 , vol. 31, # 9 p. 693 - 699

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被引用次数: 32

摘要

In the light of previous QSAR studies on flavones as inhibitors of xanthine oxidase, we synthesized and tested a new series of 7-hydroxyflavones carrying a wide and balanced variety of substituents (π, σp) at the 4′ position in order to explore the effect of substituents at this position on the xanthine oxidase inhibitory activity. The results of pKa determinations show that the electronic effects of the substituents are not transferred to the hydroxyl at C7, ...