Bioorganic & medicinal chemistry letters

Design, synthesis and biological evaluation of new arylpiperazine derivatives bearing a flavone moiety as α 1-adrenoceptor antagonists

J Jin, XB Wang, LY Kong

文献索引：Jin, Jing; Wang, Xiao-Bing; Kong, Ling-Yi Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 909 - 911

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被引用次数: 11

摘要

Elaborate study on the three-dimensional model of α1-adrenoceptor (α1-AR) antagonists led to the development of a series of new arylpiperazine derivatives bearing a flavone nucleus as α1-AR antagonists. The in vitro activities were evaluated and compounds 1, 4, 10, 13 and 15 showed activities close to the reference compound (Prazosin).