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Synthesis and inhibitory activity against COX-2 catalyzed prostaglandin production of chrysin derivatives

TT Dao, YS Chi, J Kim, HP Kim, S Kim…

文献索引：Dao, Tran Thanh; Chi, Yeon Sook; Kim, Jeongsoo; Kim, Hyun Pyo; Kim, Sanghee; Park, Haeil Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1165 - 1167

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被引用次数: 80

摘要

A series of chrysin derivatives were prepared and evaluated for their inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin production. Chrysin derivatives were prepared from 2-hydroxyacetophenone, 2, 4-dihydroxyacetophenone and 2, 6- dihydroxyacetophenone in 2 to 4 steps, respectively. Methxoylated chrysin derivatives were converted to the corresponding hydroxylated chrysin derivatives by the reaction with BBr3 ...

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