Aromatic retinoic acid analogs. Synthesis and pharmacological activity

MI Dawson, PD Hobbs, RL Chan…

文献索引：Dawson; Hobbs; Chan; Chao; Fung Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 583 - 592

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被引用次数: 41

摘要

Evidence that synthetic retinoids are capable of suppressing or reversing the transformation of premalignant epithelial cells to the malignant state'has prompted the search for new structurally modified retinoids that may possses enhanced prophylactic and therapeutic activity and reduced systemic toxicity (hypervitaminosis A). 2 The recent report3 on the synthesis and favorable biological activity of a series of aromatic analogues of retinoic ...