Aromatic retinoic acid analogs. Synthesis and pharmacological activity

MI Dawson, PD Hobbs, RL Chan…

Index: Dawson; Hobbs; Chan; Chao; Fung Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 583 - 592

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Citation Number: 41

Abstract

Evidence that synthetic retinoids are capable of suppressing or reversing the transformation of premalignant epithelial cells to the malignant state'has prompted the search for new structurally modified retinoids that may possses enhanced prophylactic and therapeutic activity and reduced systemic toxicity (hypervitaminosis A). 2 The recent report3 on the synthesis and favorable biological activity of a series of aromatic analogues of retinoic ...