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Bicyclic Oxygen Heterocycles from γ, δ??Unsaturated Alcohols: Synthetic Targets Inspired by Blepharocalyxin D

…, SJ Edwards, JD Elsworth, T Pheko…

文献索引:Bunt, Adam J.; Bailey, Christopher D.; Cons, Benjamin D.; Edwards, Sophie J.; Elsworth, Jon D.; Pheko, Tshepo; Willis, Christine L. Angewandte Chemie - International Edition, 2012 , vol. 51, # 16 p. 3901 - 3904

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被引用次数: 34

摘要

The development of strategies for the synthesis of fused heterocycles is an important goal as many such compounds display valuable properties. In this study we focus on the development of an efficient approach for the assembly of 2, 8-dioxabicyclo [4.4. 0] decanes. These scaffolds are present, for example, in the antiproliferative diarylheptanoid blepharocalyxin D (Scheme 1),[1] a rearrangement product of the antibiotic pseudomonic ...