Bicyclic Oxygen Heterocycles from γ, δ??Unsaturated Alcohols: Synthetic Targets Inspired by Blepharocalyxin D

…, SJ Edwards, JD Elsworth, T Pheko…

Index: Bunt, Adam J.; Bailey, Christopher D.; Cons, Benjamin D.; Edwards, Sophie J.; Elsworth, Jon D.; Pheko, Tshepo; Willis, Christine L. Angewandte Chemie - International Edition, 2012 , vol. 51, # 16 p. 3901 - 3904

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Citation Number: 34

Abstract

The development of strategies for the synthesis of fused heterocycles is an important goal as many such compounds display valuable properties. In this study we focus on the development of an efficient approach for the assembly of 2, 8-dioxabicyclo [4.4. 0] decanes. These scaffolds are present, for example, in the antiproliferative diarylheptanoid blepharocalyxin D (Scheme 1),[1] a rearrangement product of the antibiotic pseudomonic ...