Hydroamination/cyclization of aminoalkenes using cationic zirconocene and titanocene catalysts

DV Gribkov, KC Hultzsch

文献索引：Gribkov, Denis V.; Hultzsch, Kai C. Angewandte Chemie - International Edition, 2004 , vol. 43, # 41 p. 5542 - 5546

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被引用次数: 173

摘要

substrates to 1a at 258C results in the immediate release of methane (as observed by 1H NMR spectroscopy), but appreciable turnover is observed only at elevated temperatures. Cyclization of N-methylpent-4-enyl-amine (4) proceeds at a rate of> 50 hÀ1 in [D5] bromobenzene at 1008C (Figure 1),[10] which is roughly 20 times faster than that observed with Scott s catalyst,[8a] but slower than with [Me2Si (C5-Me4) 2NdCH (SiMe3) 2](11 hÀ1 ...