A novel method for the synthesis of 2, 2-dimethyl-1, 3-dioxolan-4-one, and its reactions with secondary amines

VI Boyko, RV Rodik, IN Severenchuk, ZV Voitenko…

文献索引：Boyko, Vyacheslav I.; Rodik, Roman V.; Severenchuk, Inna N.; Voitenko, Zoya V.; Kalchenko, Vitaly I. Synthesis, 2007 , # 14 p. 2095 - 2096

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被引用次数: 7

摘要

In early syntheses, 1,3-dioxolane 1 was used in reactions with primary amines in order to prepare monoalkyl amide derivatives. [8] Herein we describe the preparation of N,N-dialkylamides of glycolic acid. Amides 2a-g have been synthesized by the reaction of 1,3-dioxolane 1 with an excess of the appropriate amine (Scheme [2] ). ... The reactions were carried out in refluxing toluene over 10-14 hours. Analytically pure samples were obtained after distillation (2a-e ...