The Journal of Organic Chemistry

P (RNCH2CH2) 3N: An efficient promoter for the nitroaldol (Henry) reaction

PB Kisanga, JG Verkade

文献索引：Kisanga, Philip B.; Verkade, John G. Journal of Organic Chemistry, 1999 , vol. 64, # 12 p. 4298 - 4303

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被引用次数: 98

摘要

The use of catalytic amounts of the proazaphosphatranes P (MeNCH2CH2) 3N, P (i- PrNCH2CH2) 3N and P (HNCH2CH2)(i-PrNCH2CH2) 2N as nonionic bases in the reaction of nitroalkanes with carbonyl compounds is reported. The reaction proceeds at room temperature in the presence of 2.2 equiv of magnesium sulfate to produce the corresponding β-nitroalkanols in generally superior yields. Aldehydes react quantitatively ...