Milieux hyperbasiques: préparation et alkylation de carbanions en α d'amides N, N-disubstitués. Application à la synthèse de la d, l-pipéritone

P Hullot, T Cuvigny, M Larchevêque…

文献索引：Hullot,P. et al. Canadian Journal of Chemistry, 1976 , vol. 54, p. 1098 - 1104

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被引用次数: 13

摘要

The anions α to N, N-disubstituted amides can be conveniently prepared by treatment with very powerful bases," activated dialkylamides" in HMPT. These anions may react with various electrophiles especially with halogenated compounds. The use of functional halides (chloro or bromo compounds) affords functional amides. Lithiated amides are very useful intermediates in organic synthesis because they give regiospecific alkyl ketones by ...