Milieux hyperbasiques: préparation et alkylation de carbanions en α d'amides N, N-disubstitués. Application à la synthèse de la d, l-pipéritone

P Hullot, T Cuvigny, M Larchevêque…

Index: Hullot,P. et al. Canadian Journal of Chemistry, 1976 , vol. 54, p. 1098 - 1104

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Citation Number: 13

Abstract

The anions α to N, N-disubstituted amides can be conveniently prepared by treatment with very powerful bases," activated dialkylamides" in HMPT. These anions may react with various electrophiles especially with halogenated compounds. The use of functional halides (chloro or bromo compounds) affords functional amides. Lithiated amides are very useful intermediates in organic synthesis because they give regiospecific alkyl ketones by ...