Journal of the American Chemical Society

Tropylium Ion Mediated α-Cyanation of Amines

JM Allen, TH Lambert

文献索引：Allen, Julia M.; Lambert, Tristan H. Journal of the American Chemical Society, 2011 , vol. 133, # 5 p. 1260 - 1262

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被引用次数: 77

摘要

Tropylium ion mediated α-cyanation of amines is described. Even in the presence of KCN, tropylium ion is capable of oxidizing various amine substrates, and the resulting iminium ions undergo salt metathesis with cyanide ion to produce aminonitriles. The byproducts of this transformation are simply cycloheptatriene, a volatile hydrocarbon, and water-soluble potassium tetrafluoroborate. Thirteen total substrates are shown for the α-cyanation ...