Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers

A Graulich, F Mercier, J Scuvée-Moreau…

文献索引：Graulich; Mercier; Scuvee-Moreau; Seutin; Liegeois Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 4 p. 1201 - 1209

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被引用次数: 26

摘要

Neuronal action potentials are followed by an afterhyperpolarisation (AHP), which is mediated by small conductance Ca2+-activated K+ channels (SK channels or KCa2 channels). This AHP plays an important role in regulating neuronal activity and agents modulating AHP amplitude could have a potential therapeutic interest. It was previously shown that N-methyl-bicuculline iodide blocks SK channels but its GABAA activity ...