Preparation of and Fluoroalkylation with (Chlorodifluoromethyl) trimethylsilane, Difluorobis (trimethylsilyl) methane, and 1, 1, 2, 2-Tetrafluoro-1, 2-bis (trimethylsilyl) …

…, D Deffieux, M Bradley, R Bau, GA Olah

文献索引：Yudin, Andrei K.; Prakash, G. K. Surya; Deffieux, Denis; Bradley, Michael; Bau, Robert; Olah, George A. Journal of the American Chemical Society, 1997 , vol. 119, # 7 p. 1572 - 1581

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被引用次数: 77

摘要

CF2BrCl reacts with aluminum/N-methylpyrrolidinone in the presence of chlorotrimethylsilane to give Me3SiCF2Cl in high yield. Similarly, CF2Br2 gives Me3SiCF2Br with bromotrimethylsilane. Chlorodifluoromethylation of aldehydes using Me3SiCF2Cl and a catalytic amount of TBAF in polar solvents occurs at room temperature, providing difluoromethylated alcohols in two steps. Electroreduction of Me3SiCF2Cl in the presence ...