Beilstein journal of organic chemistry

Deoxygenative gem-difluoroolefination of carbonyl compounds with (chlorodifluoromethyl) trimethylsilane and triphenylphosphine

F Wang, L Li, C Ni, J Hu

文献索引：Wang, Fei; Li, Lingchun; Ni, Chuanfa; Hu, Jinbo Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 344 - 351

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被引用次数: 20

摘要

Background: 1, 1-Difluoroalkenes cannot only be used as valuable precursors for organic synthesis, but also act as bioisosteres for enzyme inhibitors. Among various methods for their preparation, the carbonyl olefination with difluoromethylene phosphonium ylide represents one of the most straightforward methods. Results: The combination of (chlorodifluoromethyl) trimethylsilane (TMSCF 2 Cl) and triphenylphosphine (PPh 3) can ...