Neuroleptics of the 8-methylthio-10-piperazino-10, 11-dihydrodibenzo [b, f] thiepin series: New compounds and new procedures

J Jílek, J Pomykáček, A Dlabač…

文献索引：Jilek; Pomykacek; Dlabac; et al. Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 2 p. 504 - 516

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被引用次数: 7

摘要

Abstract Heating of 8-methylthiodibenzo [b, f] thiepin-10 (11H)-one with mono-p- toluenesulfonates of 1-methylpiperazine and piperazine in vacuo led in good yields to the enamines IX-XI, the first of which was reduced with zinc and acetic acid to the base I (methiothepin). The ester III (oxyprothepindecanoate) was obtained by reaction of the amino alcohol II (oxyprothepin) with decanoic acid in the presence of N, N'-carbonyldiimidazole ...