The Journal of organic chemistry

Synthesis of Medium-Ring Nitrogen Heterocycles via Palladium-Catalyzed Heteroannulation of 1, 2-Dienes

RC Larock, C Tu, P Pace

文献索引：Larock, Richard C.; Tu, Chi; Pace, Paola Journal of Organic Chemistry, 1998 , vol. 63, # 20 p. 6859 - 6866

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被引用次数: 69

摘要

Seven-, eight-, and nine-membered-ring nitrogen heterocycles are readily prepared by the palladium-catalyzed heteroannulation of a variety of 1, 2-dienes by a range of tosylamide- and amine-containing aryl and vinylic halides. The ease of ring formation is seven> eight> nine, and better results are obtained using aryl halides, rather than vinylic halides, and tosylamide functionality, rather than amine functionality. The reaction is suggested to ...