The Journal of organic chemistry

Synthesis of Medium-Ring Nitrogen Heterocycles via Palladium-Catalyzed Heteroannulation of 1, 2-Dienes

RC Larock, C Tu, P Pace

Index: Larock, Richard C.; Tu, Chi; Pace, Paola Journal of Organic Chemistry, 1998 , vol. 63, # 20 p. 6859 - 6866

Full Text: HTML

Citation Number: 69

Abstract

Seven-, eight-, and nine-membered-ring nitrogen heterocycles are readily prepared by the palladium-catalyzed heteroannulation of a variety of 1, 2-dienes by a range of tosylamide- and amine-containing aryl and vinylic halides. The ease of ring formation is seven> eight> nine, and better results are obtained using aryl halides, rather than vinylic halides, and tosylamide functionality, rather than amine functionality. The reaction is suggested to ...