e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron
Tandem radical reactions of isonitriles with 2-pyridonyl and other aryl radicals: Scope and limitations, and a first generation synthesis of (±)-camptothecin
Photolysis of N-propargyl-6-halo-2-pyridones and related aromatic halides in the presence of aryl isonitriles provides tetra-and penta-cyclic products in a single step by a sequence of radical addition to the isonitrile followed by two cyclizations. The scope and limitations of the process are described along with a first generation synthesis of racemic camptothecin.
![11H-indeno[1,2-b]quinolin-11-ol Structure](https://image.chemsrc.com/caspic/376/6626-65-9.png)
![11H-indeno[1,2-b]quinoline Structure](https://image.chemsrc.com/caspic/093/243-51-6.png)
![9,11-dihydro-α-ethyl-9-oxoindolizino[1,2-b]quinoline-7-acetic acid, methyl ester Structure](https://image.chemsrc.com/caspic/033/34141-34-9.png)
![4-ethyl-1,8-dihydro-4H-pyrano[4',3':7,8]indolizino[1,2-b]quinoline-3,6-dione Structure](https://image.chemsrc.com/caspic/311/11087-69-7.png)
![4-ethyl-4-hydroxymethyl-1,8-dihydro-4H-pyrano[4',3':7,8]indolizino[1,2-b]quinoline-3,6-dione Structure](https://image.chemsrc.com/caspic/156/50906-89-3.png)
