The synthesis of a new acyclic analogue of deoxyguanosine, 9-[(1, 3-dihydroxy-2-propoxy) methyl] guanine(DHPG, l), is described starting from epichlorohydrin via condensation of 2-0- (acetoxymethyl)-l, 3-di-O-benzylglycerol (5) with N2, 9-diacetylguanine (6). In vitro studies indicate that DHPG is a potent and broad-acting (herpes simplex virus types 1 and 2, cytomegalovirus, and Epstein-Barr virus) antiherpetic agent. In vivo studies indicate its ...
[Beauchamp, Lilia M.; Serling, Barbara L.; Kelsey, John E.; Biron, Karen K.; Collins, Peter; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 144 - 149]
