Effect of acyclic pyrimidines related to 9-[(1, 3-dihydroxy-2-propoxy) methyl] guanine on herpes viruses

LM Beauchamp, BL Serling, JE Kelsey…

文献索引：Beauchamp, Lilia M.; Serling, Barbara L.; Kelsey, John E.; Biron, Karen K.; Collins, Peter; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 144 - 149

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被引用次数: 89

摘要

A series of pyrimidines related to the potent antiherpetic agent 9-[(1, 3-dihydroxy-2-propoxy) methyl] guanine(1, BW B759U), all containing the same acyclic chain, have been synthesized. Some of the compounds were derivatives of the naturally occurring bases, cytosine, uracil, and thymine; others included compounds in which the 5-position of the cytosine and uracil moieties were substituted by bromo, iodo, fluoro, methyl, and amino ...