New imidazoline/α 2-adrenoceptors affecting compounds—4 (5)-(2-aminoethyl) imidazoline (dihydrohistamine) derivatives. Synthesis and receptor affinity studies

…, R Andruszkiewicz, W Zgoda, A Walkowiak…

文献索引：Treder, Adam P.; Andruszkiewicz, Ryszard; Zgoda, Wlodzimierz; Walkowiak, Aleksandra; Ford, Celeste; Hudson, Alan L. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 156 - 167

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被引用次数: 3

摘要

Compilation of agmatine structure and imidazoline moiety leads to a new group of imidazoline/α2-adrenoceptor ligands, 4 (5)-(2-aminoethyl) imidazoline derivatives. In this study the exploration of previously unknown 4 (5)-(2-aminoethyl) imidazolines including the analogues of reported imidazoline and α2-aderenoceptors ligands: clonidine, rilmenidine, idazoxan, efaroxan, antazoline, tracizoline is described. The synthesis of a variety of novel ...