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. alpha.-Adrenoceptor reagents. 2. Effects of modification of the 1, 4-benzodioxan ring system on. alpha.-adrenoreceptor activity

CB Chapleo, PL Myers, RCM Butler…

文献索引:Chapleo, Christopher B.; Myers, Peter L.; Butler, Richard C. M.; Davis, John A.; Doxey, John C.; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 570 - 576

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被引用次数: 72

摘要

Modification of the 1, 4-benzodioxan ring present in RX 781094 (1) has not previously been considered. This paper describes a number of analogues of this ring system, including compounds in which one of the oxygen atoms has been replaced by a methylene group and also those in which the ring size has been changed to give, for example, furan and thiophene derivatives. The dihydrobenzofuranylimidazoline compound 7 is the only ...

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