General synthesis of. beta.,. gamma.-alkynylglycine derivatives

RM Williams, DJ Aldous, SC Aldous

文献索引：Williams, Robert M.; Aldous, David J.; Aldous, Suzanne C. Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4657 - 4663

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被引用次数: 62

摘要

The coupling of a-haloglycinates 8 with alkynyltin reagents produces the fully protected P, y- alkynylglycines 9. Subsequent deprotection of the amino or carboxyl groups generates differentially protected &y-alkynylglycine derivatives 10-14. The free amino acids were found to be too labile to isolate but can be generated in situ and trapped.