Lanthanide (III) Complexes That Contain a Self??Immolative Arm: Potential Enzyme Responsive Contrast Agents for Magnetic Resonance Imaging

…, R Rosseto, J Kotek, B Badet, P Durand…

文献索引：Chauvin, Thomas; Torres, Susana; Rosseto, Renato; Kotek, Jan; Badet, Bernard; Durand, Philippe; Toth, Eva Chemistry - A European Journal, 2012 , vol. 18, # 5 p. 1408 - 1418

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被引用次数: 23

摘要

Abstract Enzyme-responsive MRI-contrast agents containing a “self-immolative” benzylcarbamate moiety that links the MRI-reporter lanthanide complex to a specific enzyme substrate have been developed. The enzymatic cleavage initiates an electronic cascade reaction that leads to a structural change in the Ln III complex, with a concomitant response in its MRI-contrast-enhancing properties. We synthesized and investigated a series of Gd ...