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The Journal of Organic Chemistry

Synthesis of proxl-benzoisoallopurinol

RH Foster, NJ Leonard

文献索引：Foster, Robert H.; Leonard, Nelson J. Journal of Organic Chemistry, 1980 , vol. 45, # 15 p. 3072 - 3077

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被引用次数: 7

摘要

Pyrazolo [3, 4-flquinazolin-9-one (prox-benzoisoallopurinol, I), an extended analogue of 7- hydroxypyrazolo-[4, 3-d] pyriinidine (isoallopurinol, 2) and a potential dimensional probe for substrates of xanthine oxidase, has been synthesized by two independent routes. The title compound, prepared by elaboration of either a suitably substituted indazole or a quinazolinone, was found to be an active substrate for and an alternative-substrate ...

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