e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

The Journal of Organic Chemistry

Synthesis of proxl-benzoisoallopurinol

RH Foster, NJ Leonard

Index: Foster, Robert H.; Leonard, Nelson J. Journal of Organic Chemistry, 1980 , vol. 45, # 15 p. 3072 - 3077

Full Text: HTML

Citation Number: 7

Abstract

Pyrazolo [3, 4-flquinazolin-9-one (prox-benzoisoallopurinol, I), an extended analogue of 7- hydroxypyrazolo-[4, 3-d] pyriinidine (isoallopurinol, 2) and a potential dimensional probe for substrates of xanthine oxidase, has been synthesized by two independent routes. The title compound, prepared by elaboration of either a suitably substituted indazole or a quinazolinone, was found to be an active substrate for and an alternative-substrate ...

1H-Indazol-6-amine Structure

1H-Indazol-6-amine

~%

Ethyl 6-amino-1H-indazole-7-carboxylate Structure

Ethyl 6-amino-1...

Pyrrolo[2,3-g]indazole-7,8-dione, 1,6-dihydro- Structure

Pyrrolo[2,3-g]i...

~%

Ethyl 6-amino-1H-indazole-7-carboxylate Structure

Ethyl 6-amino-1...

6-(isonitrosoacetamido)indazole Structure

6-(isonitrosoac...

~%

Ethyl 6-amino-1H-indazole-7-carboxylate Structure

Ethyl 6-amino-1...

6-(isonitrosoacetamido)indazole Structure

6-(isonitrosoac...

~%

Pyrrolo[2,3-g]indazole-7,8-dione, 1,6-dihydro- Structure

Pyrrolo[2,3-g]i...

1H-Indazol-6-amine Structure

1H-Indazol-6-amine

~%

Pyrrolo[2,3-g]indazole-7,8-dione, 1,6-dihydro- Structure

Pyrrolo[2,3-g]i...

5H-Pyrazolo[4,3-g]quinazolin-5-one, 1,6-dihydro- Structure

5H-Pyrazolo[4,3...

~91%

1H-Pyrazolo[4,3-g]quinazoline-5,7(6H,8H)-dione Structure

1H-Pyrazolo[4,3...

4-amino-6-methyl-2-nitrobenzonitrile Structure

4-amino-6-methy...

~%

1H-Pyrazolo[4,3-g]quinazoline-5,7(6H,8H)-dione Structure

1H-Pyrazolo[4,3...

4-amino-5-methyl-2-nitrobenzamide Structure

4-amino-5-methy...

~%

1H-Pyrazolo[4,3-g]quinazoline-5,7(6H,8H)-dione Structure

1H-Pyrazolo[4,3...

6-nitroindazole-5-carboxamide Structure

6-nitroindazole...

~%

1H-Pyrazolo[4,3-g]quinazoline-5,7(6H,8H)-dione Structure

1H-Pyrazolo[4,3...

Urea Structure

6-amino-5-indazolecarboxamide Structure

6-amino-5-indaz...

~35%

1H-Pyrazolo[4,3-g]quinazoline-5,7(6H,8H)-dione Structure

1H-Pyrazolo[4,3...

7-mercaptopyrazolo[3,4-f]quinazolin-9-one Structure

7-mercaptopyraz...

~90%

1,2-dihydropyrazolo[3,4-f]quinazolin-9-one Structure

1,2-dihydropyra...

5-amino-6-methylquinazolin-4(3H)-one Structure

5-amino-6-methy...

~34%

1,2-dihydropyrazolo[3,4-f]quinazolin-9-one Structure

1,2-dihydropyra...

1H-Indazol-6-amine Structure

1H-Indazol-6-amine

~%

1,2-dihydropyrazolo[3,4-f]quinazolin-9-one Structure

1,2-dihydropyra...

6-(isonitrosoacetamido)indazole Structure

6-(isonitrosoac...

~%

1,2-dihydropyrazolo[3,4-f]quinazolin-9-one Structure

1,2-dihydropyra...

6-Methylquinazolin-4-ol Structure

6-Methylquinazo...

~%

1,2-dihydropyrazolo[3,4-f]quinazolin-9-one Structure

1,2-dihydropyra...

6-methyl-5-nitroquinazolin-4(3H)-one Structure

6-methyl-5-nitr...

~%

1,2-dihydropyrazolo[3,4-f]quinazolin-9-one Structure

1,2-dihydropyra...

6-(β-benzoylthioureido)indazole-7-carboxylic acid Structure

6-(β-benzoylthi...

~%

1,2-dihydropyrazolo[3,4-f]quinazolin-9-one Structure

1,2-dihydropyra...

Ethyl 6-amino-1H-indazole-7-carboxylate Structure

Ethyl 6-amino-1...

Formyl acetate Structure

~%

1,2-dihydropyrazolo[3,4-f]quinazolin-9-one Structure

1,2-dihydropyra...