Synthesis and biological activity of glycosyl-1H-1, 2, 3-triazoles

K Slámová, P Marhol, K Bezouška, L Lindkvist…

文献索引：Slamova, Kristyna; Marhol, Petr; Bezouska, Karel; Lindkvist, Lise; Hansen, Signe G.; Kren, Vladimir; Jensen, Henrik H. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 14 p. 4263 - 4265

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被引用次数: 30

摘要

Glycosyl 1, 2, 3-triazoles with α-d-gluco, β-d-gluco, α-d-galacto, β-d-galacto and β-2- acetamido-2-deoxygluco (GlcNAc) stereochemistry were prepared by reaction of the corresponding azides with vinyl acetate under microwave irradiation. The deprotected glucosyl and galactosyl triazoles did not display inhibitory activity against the tested glycosidases at 1mM. Of the four fungal glycosidases evaluated, GlcNAc-triazole was ...