Synthesis and Platelet Aggregation Inhibiting Activity of Acid Side??chain Modified Hydantoin Prostaglandin Analogues

P Barraclough, AG Caldwell, RC Glen…

文献索引：Barraclough; Caldwell; Glen; Harris; Stepney; Whittaker; Whittle Archiv der Pharmazie, 1993 , vol. 326, # 2 p. 85 - 95

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被引用次数: 4

摘要

Abstract A series of hydantoin prostaglandin analogues, in which the hexamethylene moiety of the acid side chain was replaced by other spacing groups possessing either ether, sulphide and/or olefin functionality, were prepared and evaluated for platelet aggregation inhibiting activity. The 4-thia analogue 13 proved to be the most potent inhibitor (ca. 22x PGE 1) and the 3-thia-and 3-oxa-analogues, 6 and 10 respectively, are approximately ...