Tandem Enzymatic Resolution Yielding L-. ALPHA.-AminoaLkanedioic Acid. OMEGA.-Esters.

N NISHINO, T ARAI, Y UENO, M OHBA

文献索引：Nishino, Norikazu; Arai, Toru; Ueno, Yukio; Ohba, Masataka Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 212 - 214

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被引用次数: 8

摘要

The tandem action of serine protease (α-chymotrypsin or subtilisin BPN') and Aspergillus genus aminoacylase on racemic N-acetyl-α-aminoalkanedioic acid α, ω-diester produced L- α-aminoalkanedioic acid ω-ester in good yield and high optical purity. L-α-Aminosuberic acid ω-ester thus obtained was conveniently introduced into an oxytocin analog,[Asu 1, 6] oxytocin, by the solid-phase-synthesis and cyclization-cleavage method with oxime resin.