Tandem Enzymatic Resolution Yielding L-. ALPHA.-AminoaLkanedioic Acid. OMEGA.-Esters.

N NISHINO, T ARAI, Y UENO, M OHBA

Index: Nishino, Norikazu; Arai, Toru; Ueno, Yukio; Ohba, Masataka Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 212 - 214

Full Text: HTML

Citation Number: 8

Abstract

The tandem action of serine protease (α-chymotrypsin or subtilisin BPN') and Aspergillus genus aminoacylase on racemic N-acetyl-α-aminoalkanedioic acid α, ω-diester produced L- α-aminoalkanedioic acid ω-ester in good yield and high optical purity. L-α-Aminosuberic acid ω-ester thus obtained was conveniently introduced into an oxytocin analog,[Asu 1, 6] oxytocin, by the solid-phase-synthesis and cyclization-cleavage method with oxime resin.

Inhibitors selective for HDAC6 in enzymes and cells

[Gupta, Praveer K.; Reid, Robert C.; Liu, Ligong; Lucke, Andrew J.; Broomfield, Steve A.; Andrews, Melanie R.; Sweet, Matthew J.; Fairlie, David P. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 23 p. 7067 - 7070]

Design, synthesis, potency, and cytoselectivity of anticance...

[Kahnberg, Pia; Lucke, Andrew J.; Glenn, Matthew P.; Boyle, Glen M.; Tyndall, Joel D. A.; Parsons, Peter G.; Fairlie, David P. Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7611 - 7622]

Reaktionen von Glutaminsäuredimethylester im Massenspektrome...

[Lerch,E.; Hesse,M. Helvetica Chimica Acta, 1974 , vol. 57, p. 1584 - 1597]

Synthesis and Platelet Aggregation Inhibiting Activity of Ac...

[Barraclough; Caldwell; Glen; Harris; Stepney; Whittaker; Whittle Archiv der Pharmazie, 1993 , vol. 326, # 2 p. 85 - 95]