Preparation of optically active 2-thienylcarbinols by kinetic resolution using the Sharpless reagent

Y Kitano, M Kusakabe, Y Kobayashi…

文献索引：Kitano, Yasunori; Kusakabe, Masato; Kobayashi, Yuichi; Sato, Fumie Journal of Organic Chemistry, 1989 , vol. 54, # 4 p. 994 - 996

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被引用次数: 19

摘要

1985, 50, 5446. from the remaining la. 9 The kinetic resolution of various 1, therefore, was carried out by using 3 equiv of TBHP, and the remaining chiral 1 was isolated by filtration through a short silica gel column after usual workup; the results are summarized in Table I. It can be seen from the table that the efficiency of the kinetic resolution depends on the steric bulk of the substituent (R2) at carbinol carbon and decreases with increasing bulk of R2. ...