Preparation of optically active 2-thienylcarbinols by kinetic resolution using the Sharpless reagent

Y Kitano, M Kusakabe, Y Kobayashi…

Index: Kitano, Yasunori; Kusakabe, Masato; Kobayashi, Yuichi; Sato, Fumie Journal of Organic Chemistry, 1989 , vol. 54, # 4 p. 994 - 996

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Citation Number: 19

Abstract

1985, 50, 5446. from the remaining la. 9 The kinetic resolution of various 1, therefore, was carried out by using 3 equiv of TBHP, and the remaining chiral 1 was isolated by filtration through a short silica gel column after usual workup; the results are summarized in Table I. It can be seen from the table that the efficiency of the kinetic resolution depends on the steric bulk of the substituent (R2) at carbinol carbon and decreases with increasing bulk of R2. ...