Importance of the aromatic ring in adrenergic amines. 5. Nonaromatic analogs of phenylethanolamine as inhibitors of phenylethanolamine N-methyltransferase: role of …

…, CS Aldrich, RT Borchardt, GL Grunewald

文献索引：Vincek, William C.; Aldrich, Constance S.; Borchardt, Ronald T.; Grunewald, Gary L. Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 7 - 12

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被引用次数: 21

摘要

The synthesis of five classes [type A, cycloalkylethanolamines; type B, n-alkylethanolamines; type C, 2-(aminomethyl)-2-n-alkanols; type D, 1-(aminomethy1) cycloalkanols; type E, sec- akylethanolamiies] of nonaromatic analogues of P-phenylethanolamine and an evaluation of their inhibitory potency (ICw) for phenylethanolamine N-methyltransferase (PNMT) are described. The key intermediates for the synthesis of the ethanolamines were the ...