18-Cycloalkyl analogs of enisoprost

…, AF Gasiecki, WE Perkins, GW Gullikson…

文献索引：Collins, Paul W.; Gasiecki, Alan F.; Perkins, Willam E.; Gullikson, Gary W.; Jones, Peter H.; Bauer, Raymond F. Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1001 - 1006

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被引用次数: 7

摘要

By use of standard cuprate methodology, a series of 18-cycloalkyl analogues of enisoprost was prepared in an effort to impede w chain metabolism and prolong duration of gastric antisecretory activity. An initial product of w chain oxidation, the C-20 hydroxy analogue, was also synthesized for pharmacological comparison. The cyclopropyl, cyclobutyl, and cyclopentyl analogues were approximately one-fourth as potent as enisoprost in inhibiting ...