Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido [1, 2-e] purin-4 (3H)-one derivatives

G Xia, J Li, A Peng, S Lai, S Zhang, J Shen, Z Liu…

文献索引：Xia, Guangxin; Li, Jianfeng; Peng, Aiming; Lai, Shunan; Zhang, Shujun; Shen, Jingshan; Liu, Zhonghua; Chen, Xinjian; Ji, Ruyun Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2790 - 2794

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被引用次数: 31

摘要

Synthesis and primary SAR of a novel series of 2-phenylpyrido [1, 2-e] purin-4 (3H)-one derivatives with piperazinyl sulfonamide substituents were described herein. As potential PDE5 inhibitors for erectile dysfunction (ED) treatment, representative compounds exhibit improved selectivity versus PDE1 and PDE6. Meanwhile, compound 3e demonstrated functional efficacy on rabbit corpus cavernosum strip in vitro.