Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido [1, 2-e] purin-4 (3H)-one derivatives

G Xia, J Li, A Peng, S Lai, S Zhang, J Shen, Z Liu…

Index: Xia, Guangxin; Li, Jianfeng; Peng, Aiming; Lai, Shunan; Zhang, Shujun; Shen, Jingshan; Liu, Zhonghua; Chen, Xinjian; Ji, Ruyun Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2790 - 2794

Full Text: HTML

Citation Number: 31

Abstract

Synthesis and primary SAR of a novel series of 2-phenylpyrido [1, 2-e] purin-4 (3H)-one derivatives with piperazinyl sulfonamide substituents were described herein. As potential PDE5 inhibitors for erectile dysfunction (ED) treatment, representative compounds exhibit improved selectivity versus PDE1 and PDE6. Meanwhile, compound 3e demonstrated functional efficacy on rabbit corpus cavernosum strip in vitro.