Kinetic chiral resolutions of 1, 2-diols and desymmetrization of glycerol catalyzed by glycerol kinase

HK Chenault, LF Chafin, S Liehr

文献索引：Keith Chenault; Chafin, Laura F.; Liehr, Sebastian Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4039 - 4045

全文：HTML全文

被引用次数: 26

摘要

Enantioselective phosphorylation catalyzed by glycerol kinase (EC 2.7. 1.30) facilitated the kinetic chiral resolution of 3-chloro-1, 2-propanediol, 3-fluoro-1, 2-propanediol, 3-butene-1, 2-diol, and 1, 2, 4-butanetriol. Both enantiomers of each compound were isolated in free diol or triol form, in excellent enantiomeric purity (91 to> 99.5% ee) and in moderate to good yield (60-94% of theoretical). The enantioselectivities of glycerol kinase from different ...