“Cassette” In Situ Enzymatic Screening Identifies Complementary Chiral Scaffolds for Hydrolytic Kinetic Resolution Across a Range of Epoxides

…, DR Powell, C Hu, DB Berkowitz

文献索引：Dey, Sangeeta; Powell, Douglas R.; Hu, Chunhua; Berkowitz, David B. Angewandte Chemie - International Edition, 2007 , vol. 46, # 37 p. 7010 - 7014

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被引用次数: 31

摘要

For combinatorial catalysis,[1, 2] rapid and information-rich screening methods are very useful. Toward this end, we describe herein a new “cassette” in situ enzymatic screening (ISES) approach that allows the experimentalist to obtain a parallel readout on substrate specificity, as well as a sense and magnitude of enantioselectivity.[3] In its first iteration, cassette-ISES is used to “cherry pick” only those catalysts in the array that show high ISES ...