Synthesis and stereospecificity of 4, 5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA

CM Orac, S Zhou, JA Means, D Boehm…

文献索引：Orac, Crina M.; Zhou, Shu; Means, John A.; Boehm, David; Bergmeier, Stephen C.; Hines, Jennifer V. Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6786 - 6795

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被引用次数: 26

摘要

The enantiomers and the cis isomers of two previously studied 4, 5-disubstituted oxazolidinones have been synthesized, and their binding to the T-box riboswitch antiterminator model RNA has been investigated in detail. Characterization of ligand affinities and binding site localization indicates that there is little stereospecific discrimination for binding antiterminator RNA alone. This binding similarity between enantiomers is likely ...