Amination of Ketones by Employing Two New (S)??Selective ω??Transaminases and the His??Tagged ω??TA from Vibrio fluvialis

…, JH Sattler, A Lerchner, A Skerra…

文献索引：Mutti, Francesco G.; Fuchs, Christine S.; Pressnitz, Desiree; Turrini, Nikolaus G.; Sattler, Johann H.; Lerchner, Alexandra; Skerra, Arne; Kroutil, Wolfgang European Journal of Organic Chemistry, 2012 , # 5 p. 1003 - 1007

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被引用次数: 16

摘要

Abstract Two recently identified (S)-selective ω-transaminases (ω-TAs) that originate from Paracoccus denitrificans (Strep-PD-ωTA, cloned with an N-terminal Strep-tag II) and Pseudomonas fluorescens (PF-ωTA) were employed for the asymmetric amination of selected prochiral ketones. The substrates tested were transformed into optically pure amines (> 99% ee) with high conversion (up to> 99%). The ω-TAs led to higher ...