New antifungal 1, 2, 4-triazoles with difluoro (substituted sulfonyl) methyl moiety.

…, Y Kaneko, S Takeda, M TOKIZAWA, S SATO…

文献索引：Eto; Kaneko; Takeda; Tokizawa; Sato; Yoshida; Namiki; Ogawa; Maebashi; Ishida; Matsumoto; Asaoka Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 2 p. 173 - 182

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被引用次数: 27

摘要

New 1, 2, 4-triazoles (2) having a difluoro (substituted sulfonyl) methyl moiety were designed and synthesized via α, α-difluoro-α-(substituted thio) acetophenones (3). Compounds (2) showed potent antifungal activities against C. albicans, C. krusei, A. flavus and A. fumigatus in vitro and against C. albicans in vivo for oral and iv administrations. Especially,(−)-2a,(−)- 2b and (−)-2d showed potent antifungal activities.