Tetrahedron

Enantioselective synthesis of α, β-substituted β-amino acids

C Agami, S Cheramy, L Dechoux, M Melaimi

文献索引：Agami, Claude; Cheramy, Sandrine; Dechoux, Luc; Melaimi, Mohand Tetrahedron, 2001 , vol. 57, # 1 p. 195 - 200

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被引用次数: 20

摘要

Chiral derivative 3 was shown to be a precursor of α and β-substituted β-amino acids as well as α, β-disubstituted β-amino acids. The key steps of the procedure are a diastereoselective alkylation of synthon 3 by organocuprates reagents and a diastereoselective alkylation of the alkylated adduct.