Enantioselective synthesis of β-amino acids. 7. Preparation of enantiopure α-substituted β-amino acids from 1-benzoyl-2 (S)-tert-butyl-3-methylperhydropyrimidin-4- …

…, D Quintana, M Balderas, E García-Pérez

文献索引：Juaristi, Eusebio; Quintana, Delia; Balderas, Margarita; Garcia-Perez, Enrique Tetrahedron Asymmetry, 1996 , vol. 7, # 8 p. 2233 - 2246

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被引用次数: 103

摘要

Inexpensive natural α-amino acid L-asparagine was efficiently converted to either (R)-or (S)- α-alkylated β-amino acids in enantiomerically pure state. The key intermediate in this protocol is the enantiopure N, N-acetal pyrimidinone (S)-1, a masked chiral derivative of β- alanine.