Dynamic kinetic resolution of racemic β-haloalcohols: direct access to enantioenriched epoxides

…, V Ritleng, M Pfeffer, DB Janssen…

文献索引：Elenkov, Maja Majeric; Tang, Lixia; Hauer, Bernhard; Janssen, Dick B. Organic Letters, 2006 , vol. 8, # 19 p. 4227 - 4229

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被引用次数: 83

摘要

The direct chemo-enzymatic DKR of racemic β-haloalcohols is reported, yielding the corresponding optically active epoxides in a single step. The mutant haloalcohol dehalogenase HheC Cys153Ser Trp249Phe is used for the asymmetric ring closure,