New synthetic route to pheniramines via hydroformylation of functionalyzed olefins

…, G Del Ponte, M Marchetti, S Paganelli

文献索引：Botteghi, Carlo; Chelucci, Giorgio; Ponte, Gino Del; Marchetti, Mauro; Paganelli, Stefano Journal of Organic Chemistry, 1994 , vol. 59, # 23 p. 7125 - 7127

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被引用次数: 31

摘要

One of the most important class of antihistaminic agents is represented by pheniramines 1 (Figure l). 1, 2 Industrially, they are manufactured in racemic form by base-promoted reaction of phenylacetonitrile (or its p-chloro-and p-bromo derivatives) with 2-chloropyridine followed by alkylation of the resulting 2-pyridylphenylacetonitrile with 2-(dimethy1amino) ethyl chloride and by removal of the cyano