Tetrahedron Letters

A practical one-pot synthesis of 2, 3-disubstituted indoles from unactivated anilines

M Tokunaga, M Ota, M Haga, Y Wakatsuki

文献索引：Tokunaga, Makoto; Ota, Mitsuru; Haga, Masa-aki; Wakatsuki, Yasuo Tetrahedron Letters, 2001 , vol. 42, # 23 p. 3865 - 3868

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被引用次数: 63

摘要

The indole skeleton is an important element in many pharmacologically active compounds and there is still a strong demand for a versatile, efficient, and regioselective synthesis. 1 The classical Fischer indole synthesis 2 has been used for more than 100 years and is the most common and versatile method known, but has difficulties associated with the use of arylhydrazine precursors to produce an arylhydrazone intermediate. Recently, this precursor has been elegantly ...